RUFATE - Sucralfate 1gm./10ml. Solution

Composition Each syrup contains: Sucralfate 1gm./10ml. Solution Product Description Sucralfate is an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers. Mechanism of Action sucralfate is a sucrose sulfate-aluminum complex that binds to the hydrochloric acid in the stomach and acts like an acid buffer with cytoprotective properties. Pharmaco Kinetics Bioavailability - 3-5% (local acting) ; Metabolism - GI, liver: unknown ; Half life - unknown Excretion - feces, urine . Indications approved indication for sucralfate is for the treatment of active duodenal ulcers not related to NSAID usage because the mechanism behind these ulcers is secondary to acid oversecretion. It is not technically approved for gastric ulcers because the main mechanism is not due to acid oversecretion but rather from diminished protection.

Dosage Active Duodenal Ulcer The recommended adult oral dosage for duodenal ulcer is 1 g four times per day on an empty stomach. Maintenance Therapy The recommended adult oral dosage is 1 g twice a day. Elderly In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Contra Indication There are no known contraindications to the use of sucralfate. Special Precautions Not to be used with pregnant woman, nursing mothers. Pediatric use is not recommended. Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline. Adverse Effects The most common side effects seen are constipation and bezoar formation. Less commonly reported include flatulence, cephalalgia (headache), hypophosphatemia, and xerostomia (dry mouth). Nursing mothers: Uncertain. Packing A bottle of 200 ml.