REXIME 250/500 - Cefuroxime Axetil Tabs.

Composition Rexime 250: Cefuroxime Axetil 250 mg. Rexime 500: Cefuroxime Axetil 500 mg. Rexime DS: Cefuroxime Axetil Dry Syrup. Product Description Cefuroxime Axetil Cefuroxime is a second-generation cephalosporin antibiotic that has been widely available.> Mechanism of Action As for the cephalosporins, although as a second-generation it is less susceptible to Beta-lactamase and so may have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae and Lyme disease. Pharmaco Kinetics Bioavailability - 37% on empty stomach, up to 52% if taken after food ; Metabolism - axetil moiety is metabolized to acetaldehyde and acetic acid ; Half life - 80 minutes. Indications Cefuroxime axetil tablets are indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated micro-organisms. Contra Indication The following hypersensitivity reactions have been reported: anaphylaxis, angioedema, pruritus, rash, serum sickness-like reaction, urticaria. Special Precautions Pregnancy: This drug should be used during pregnancy only if clearly needed. Labor and Delivery: Cefuroxime axetil has not been studied for use during labor and delivery. Nursing Mothers: Because cefuroxime is excreted in human milk, consideration should be given to discontinuing nursing temporarily during treatment with cefuroxime axetil. Drug Interactions Drugs that reduce gastric acidity may result in a lower bioavailability of REXIME compared with that of fasting state and tend to cancel the effect of postprandial absorption. In common with other antibiotics, cefuroxime axetil may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

Dosage Adolescents and Adults (13 years and older) Indication Dosage Duration / Days Pharyngitis/tonsillitis 250 mg b.i.d. 10 Acute bacterial maxillary sinusitis 250 mg b.i.d. 10 Acute bacterial exacerbations of chronic bronchitis 250 or 500 mg b.i.d. 10 Secondary bacterial infections of acute bronchitis 250 or 500 mg b.i.d. 5-10 Uncomplicated skin and skin-structure infections 250 or 500 mg b.i.d. 10 Uncomplicated urinary tract infections 250 mg b.i.d. 7-10 Uncomplicated gonorrhea 1,000 mg once single dose Early Lyme disease 500 mg b.i.d. 20 Pediatric Patients (who can swallow tablets whole) Indication Dosage Duration / Days Acute otitis media 250 mg b.i.d. 10 Acute bacterial maxillary sinusitis 250 mg b.i.d. 10 Adverse Effects Occassionally Nausea, GI Disturbance, Vomiting, Skin Rash. Packing A strip of 10 tablets, for both 250 / 500 mg.