R-COBOL - Mecobalamin 750mcg, Pyridoxin 2mg, Folic Acid 1.5mg & Alpha Lipoic Acid 100mg Cap. & Syp / Mecobalamin 500mcg Inj.

Composition Each capsule contains: Mecobalamin 750mcg, Pyridoxin 2mg, Folic Acid 1.5mg & Alpha Lipoic Acid 100mg. Product Description Mecobalamin Vitamin B12, a member of B-Vitamin family is a collective term for a group of cobalt containing compounds known as Corrinoids. The principle Cobalamin are Cynacobalamin, Hydroxycobalamin and the two active co-enzyme form of Vitamin B12 Methylcobalamin Mechanism of Action Mecobalamin it helps in the formation of myelin sheath, promotes growth and regeneration of nerve cells. Pharmaco Kinetics On oral administration all forms of B12 bind to proteins called haptocorrins or R proteins. Pancreatic proteases partially degrade the B12-haptocorrin complexes in the small intestine where the B12 that is released then binds to intrinsic factor (IF). B12 is released from the B12-IF complex and then binds to another protein called transcobalamin II which delivers it to the portal circulation. The portal circulation transports B12 to the liver, which takes up about 50% of the vitamin; the reminder is transported to the other tissues of the body via the systemic circulation. Vitamin B12 in the circulation is bound to the plasma protein transcobalamins TCI, TCII and TCIII. Approximately 80% of plasma B12 is bound to TCI. TCII is the principal B12 binding protein for the delivery of B12 to cells, via specific receptors for TCII. Vitamin B12 is secreted in the bile and reabsorbed via the entero-hepatic circulation. Some of the B12 secreted in the bile is excreted in the feces.

Indications Neurological illness, Fatigue and general weakness All types of Neuropathy, Arthritis, Diabetes and CAD Dosage One to two capsules per day Contra Indication Hypersensitivity to any component of Vitamin b12 Special Precautions If you are pregnant or breast feeding, consult your health care professional before using this product Drug Interactions Dosage can be increased with concomitant administration with anti-convulsants, PPIs, Antibiotics and other acid suppressants. Adverse Effects Occasional reports of hypersensitivity reaction, Urticaria, rash and Pruritis Packing A strip of 10 tablets.