RAJTHER - a ß Arteether 150mg / 2ml Inj.

Composition Each Inj. Contains : a ß Arteether 150mg / 2ml Inj. Product Description a ß Arteether is a synthetic derivative of artemisinin, a product of Chinese plant Artemisia annua Mechanism of Action a / ß arteether is a fast acting blood schizonticidal agent for P. falciparum malaria at the erythrocytic stage. a /ß arteether is concentrated in parasitized erythrocytes. The functional group responsible for antimalarial activity of a / ß arteether is endoperoxide bridge. Iron from the digested haemoglobin of the parasite's victim reduces this bridge, releasing a highly reactive free radical iron species which causes lysis of the parasitic cell. Lysis of parasitic cell membrane occurs. Damage includes swelling and deformity of food vacuoles membrane, nuclear membrane, endoplasmic reticulum and formation of autophagic vacuoles. It is also proposed that a / ß arteether inhibits the protein synthesis and alters the ribosomal organization and endoplasmic reticulum. Pharmaco Kinetics a / ß arteether is transformed into dihydroartemisinin. It has a half life of 20 hours. It is eliminated by hepatic metabolism. The elimination is much slower compared to other compounds.

Indications It is specifically indicated for the treatment of chloroquine resistant P. falciparum malaria and cerebral malaria cases. Dosage 1 vial everyday for 3 days. Contra Indication a ß arteether injection is contraindicated in patients hypersensitive to artemisinin derivatives. Special Precautions Not to be used with pregnant and nursing mothers. Drug Interactions Prolonged QT interval has been reported in some studies with high dosage of artemisinin derivatives. The cardiac effects of artemisinins are not very important from a clinical point of view, except that caution should be exercised against combinations with other drugs that prolong the QT interval, such as quinine and halofantrine. Adverse Effects Headache, constipation, and dizziness are the most commonly reported side effects associated with its use. Packing Three vials of 2 ml. each